Covid-19 Omicron subvariant XBB.1 strongest by far in vaccine evasion, Hong Kong expert says, warning of arrival of more winter strains


A new coronavirus subvariant called XBB.1 that was recently detected for the first time in Hong Kong has the strongest ability by far to evade vaccine protection, a leading expert has warned, adding travellers could bring in more new strains in winter under eased border curbs.

But Dr Gilman Siu Kit-hang, associate professor of the department of health technology and informatics at Polytechnic University, on Wednesday said vaccination remained effective in preventing severe conditions.

Siu said research had indicated the Omicron subvariant XBB.1, detected in an imported infection that was reported on Monday, stemmed from a combination of BA.2.10 and BA.2.75, and was found to be more evasive to vaccine immunity than other known variants.

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“Research from Peking University showed that it has the strongest ability to evade vaccines among variants at the moment,” he told a radio programme.

Siu said XBB.1 was first found in Singapore, while Nepal and Bangladesh had also recorded cases of the subvariant.

He added it was difficult to predict if XBB.1, which accounts for about 1 per cent of global infections, would become the dominant strain in Hong Kong, as residents who opted to travel overseas under the “0+3” arrangement – no hotel quarantine for arrivals but three days of home medical surveillance with limited citywide movement – could bring back new variants from abroad.

Dr Gilman Siu from PolyU. Photo: Xiaomei Chen

Siu said he expected more mutant strains to emerge in winter and the number of infections to rise, urging health authorities to closely monitor the situation.

“This winter is the first winter since many places over the world returned to normal. Variants are expected to keep emerging,” he cautioned.

But he said patients infected with Omicron subvariants would have similar clinical responses with a low chance of developing severe symptoms unless an entirely new Covid-19 strain emerged.

Siu added the focus of measuring the pandemic’s severity should be on cases with severe conditions and variants spreading globally, rather than the number of confirmed infections and variants identified.

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Health officials on Monday reported the city’s first imported XBB.1 case involving a 50-year-old woman who arrived on September 25 from the United States.

Chief Executive John Lee Ka-chiu on Tuesday also cited the arrival of new subvariants in the city as a factor when he cautioned against pushing ahead with the lifting of the three days of home medical surveillance for inbound travellers.

“Even though the current assessment is that the harm they may cause might not be bigger than the existing virus in our communities, we need to pay attention,” he said.

Secretary for the Civil Service Ingrid Yeung Ho Poi-yan, who was on a tour of a vaccination centre on Wednesday also argued that the winter season and potential new variants were reasons for parents to get their children inoculated.

“If we bring children for travel, we should give them enough protection, as it will be more complicated if they get infected abroad, such as language difficulties and unfamiliarity with the medical systems there,” she said.

Yeung added that for adequate two-dose protection before the Christmas peak travel season, parents would need to arrange the first jab for their children in mid-November.

Hong Kong authorities to comply with ban on invalidating 20,000 jab exemptions

Meanwhile, the High Court on Tuesday imposed a temporary ban on authorities from invalidating more than 20,000 Covid-19 vaccination exemption certificates issued by seven doctors alleged to have produced fraudulent documents, after a resident lodged a judicial review. The Health Bureau had earlier indicated the exemptions would be nullified from Wednesday.

Health authorities said they would comply with the court order.

A vaccination service centre in Tsing Yi. Experts say the jabs still offer effective protection against serious conditions. Photo: Felix Wong

Alex Lam Chi-yau, chairman of the non-profit Hong Kong Patients’ Voices, on Wednesday said some residents with the certificates in question had found it hard to seek new ones as some doctors had refused to issue the documents.

Hong Kong on Tuesday recorded 4,656 coronavirus infections, 373 of which were imported, and nine more deaths. The city’s overall tally stands at 1,811,344 cases and 10,237 related fatalities.

Additional reporting by Victor Ting

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