The 29-year-old Penangite, who received a bye in the first round, needed just 31 minutes to beat Cardwell 11-7, 11-5, 11-4 in the second round on Friday.
Second seed Perry, who also had a bye in the first round, faced a strong challenge from Mayar Hany of Egypt before prevailing 11-5, 9-11, 11-4, 11-5.
World No. 25 Wee Wern, seeded eighth here, said it was a good win over Cardwell and was optimistic about the match against Perry, especially after her stunning win over world No. 8 Amanda Sobhy of the US in the second round of the Carol Weymuller Open last month.
“It took me a while to get used to the court condition but I did well to win in straight sets.
“I will face a tough challenge against Perry, who won the British National Championships title last week. She is ranked world No. 7, so there is no pressure on me.
“I just hope to play well and take down a top 10 player again in a tournament,” said Wee Wern.
Top seed Sobhy also reached the quarter-finals by beating Nicole Bunyan of Canada 11-5, 12-10, 11-1 in the second round. She will face fifth seed Nele Gilis of Belgium for a place in the semi-finals.
Wee Wern’s younger sister Weenee, who is based in the US and played in the tournament as a wild card, however, lost in the first round to Emilia Soini of Finland 3-11, 4-11, 2-11.
First round: Nicole Bunyan (Can) bt Ineta Mackevica (Lat) 4-11, 8-11, 6-11, 11-7, 12-10; Menna Nasser (Egy) bt Jessica Turnball (Aus) 15-13, 2-11, 11-9, 11-13, 11-8; Nada Abbas (Egy) bt Sunayna Kuruvilla (Ind) 8-11, 11-5, 11-6, 9-11, 11-6; Emilia Soini (Fin) bt Weenee Low (Mas) 11-3, 11-4, 11-2; Nikki Todd (Can) bt Jasmine Hutton (Eng) 12-10, 12-10, 8-11, 4-11, 11-6; Enora Villard (Fra) bt Cindy Merlo (Sui) 11-7, 11-9, 11-5; Sarah Cardwell (Aus) bt Tessa ter Sluis (Hol) 11-6, 8-11, 11-8; 5-11, 11-9; Mayar Hany (Egy) bt Catalina Peleaz (Col) 12-10, 11-4, 11-6.
Second round: Amanda Sobhy (US) bt Nicole Bunyan (Can) 11-5, 12-10, 11-1; Nele Gilis (Bel) bt Menna Nasser (Egy) 11-6, 11-6, 11-0; Rowan Elaraby (Egy) bt Nada Abbas (Egy) 11-7, 11-3, 9-11, 12-10; Hania El Hammamy (Egy) bt Emilia Soini (Fin) 11-5, 11-8, 11-5; Olivia Blatchford Clyne (US) by Nikki Todd (Can) 11-7, 11-3, 11-7; Tinne Gilis (Bel) bt Enora Villard (Fra) 11-6, 11-5, 11-6; Low Wee Wern (Mas) bt Sarah Cardwell (Aus) 11-7, 11-5, 11-4; Sarah-Jane Perry (Eng) bt Mayar Hany (Egy) 11-5, 9-11, 11-4, 11-5.