In a statement on his Facebook page, Khairuddin said that he has talked extensively with Interpol agents to place Low and former SRC International managing director Nik Faisal Ariff Kamil under its "red alert" watch.
Khairuddin said that the duo should be tracked down so that they can be arrested and returned to Malaysia.
"We know where they are," he said.
"Jho Low must be held responsible for his treachery in the embezzlement of billions of government funds and the people's money in the 1MDB scandal," said Khairuddin.
Khairuddin said both Low and Nik Faisal are "key" in closing the 1MDB case.
"If we manage to bring home Jho Low and Nik Faisal Ariff Kamil, I am very confident that every detail of the 1MDB scandal will be known in detail," he said.
However, he stressed that the two will be brought back to Malaysia to face the court in a professional, transparent and fair manner.
He described the 1MDB case as the "largest financial scandal in the world" and vowed to do what he can to help the Government to close the 1MDB case.
Khairuddin has been renewing his complaints with several foreign authorities over the 1MDB scandal over the past few months.
He has made reports over 1MDB in Australia, Switzerland and America.
Khairuddin and his lawyer Matthias Chang were detained under the Security Offences (Special Measures) Act 2012 (Sosma) over his reports on 1MDB with foreign authorities in 2015.
He was acquitted of the charge last year.
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