Bivalent Covid-19 vaccines gaining traction in the West


Vaccines that target both the original SARS-CoV-2 viral strain and the Omicron variant are rapidly being approved by health authorities around the world. — AFP

France became the latest country on Sept 20 (2022) to authorise new Covid-19 vaccines that have been updated to target the SARS-CoV-2 Omicron viral subvariants ahead of the autumn booster campaign.

Here's what you need to know about these "bivalent" vaccines, which means they also still target the original strain that emerged in the Chinese city of Wuhan in 2019.

Two of the first vaccines developed to fight the original strain were made by the US-German team of Pfizer-BioNTech and by US firm Moderna, both using new mRNA (messenger ribonucleic acid) technology.

While traditional vaccines use a weakened or inactivated germ to prepare the body for a future attack from the real virus, mRNA deploys snippets of genetic material that carry instructions showing the body's cells how to produce a protein – in this case, the SARS-CoV-2 virus' famous spike protein.

The body's immune system then triggers antibodies to fight off that spike protein, making it ready for when the real coronavirus comes knocking.

However, the virus has mutated throughout the pandemic, growing new spikes to help it evade the immune response built up by the original vaccines.

The Omicron variant, which has milder symptoms, but is more infectious, has become dominant across the world this year (2022) – particularly its subvariants BA.4 and BA.5 in recent months.

Vaccine-makers have been racing to catch up, aiming to provide updated booster shots ahead of an expected new wave of Covid-19 cases in the northern hemisphere's winter.

Aiming for BA.4 and BA.5

Pfizer-BioNTech and Moderna first tweaked their original vaccines to include the spike protein seen in the BA.1 subvariant, while also still targeting the original strain.

Then both vaccines were further tweaked to include the spike proteins on the BA.4 and BA.5 subvariants.

The US Food and Drug Administration (FDA) approved both BA.4/5 vaccines late last month (August 2022), and officials there hope millions of Americans will receive bivalent boosters throughout September (2022).

The European Union's medicines watchdog, the European Medicines Agency (EMA), approved Moderna and Pfizer-BioNTech's BA.1 vaccines at the start of this month (September 2022).

The EMA then approved Pfizer-BioNTech's BA.4/5 last week, saying its recommendation was based on clinical data from the older BA.1 version.

Canada meanwhile authorised Moderna's BA.1 vaccine at the start of September (2022).

Clinical trial data remains sparse for the newest BA.4/5 vaccines, which the US approved based on animal studies showing they produced a greater immune response and lowered levels of the virus in the lungs, compared to older shots.

University of Geneva Institute of Global Health director Antoine Flahault said he was "still not convinced" about the superior efficacy of the BA.4/5 vaccines because there had not yet been clinical trials into their effectiveness.

However, the vaccines are "very promising" and have no new safety concerns, he said, adding that there would be much more data in the coming weeks as the US bivalent booster campaign gains steam.

Adapting without trial

The concept of adapting a new vaccine without carrying out full clinical trials every time is not a new one.

Influenza vaccines are updated annually, and are now quadrivalent, targeting components of two influenza A and two influenza B viruses.

US health officials have said that in the future, newly-updated Covid boosters could be recommended every year, similar to influenza vaccines, unless drastically different variants emerge.

Other vaccine-makers are also working on bivalent jabs, including one from France's Sanofi and the United Kingdom's GSK that targets the earlier Delta and Beta strains.

The EMA is reviewing that vaccine, as well as another from the Spanish pharma firm HIPRA, targeting the Alpha and Beta strains. – AFP Relaxnews

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