Covid-19 vaccines appear to affect some women's periods

Although disturbances to menstruation is not one of the listed common side effects of any Covid-19 vaccine, some women have reported such occurrences after they were inoculated. — AFP

Some women say their periods change after getting a Covid-19 vaccination.

In an editorial published in The BMJ on Sept 19 (2021), Imperial College London reproductive specialist Dr Victoria Male opines that a link between menstrual changes after Covid-19 vaccination is plausible and should be investigated.

Changes to periods or unexpected vaginal bleeding are not listed as common side effects of Covid-19 vaccination, she writes.

Yet, more than 30,000 such reports had been made to the UK Medicines and Healthcare Products Regulatory Agency (MHRA) surveillance scheme for adverse drug reactions by Sept 2 (2021).

However, most people find that their period returns to normal the following cycle, and importantly, there is no evidence that Covid-19 vaccination adversely affects fertility.

The MHRA states that its surveillance data does not support a link between changes to menstrual periods and Covid-19 vaccines, as the number of reports is low in relation to both the number of people vaccinated and the prevalence of menstrual disorders generally.

However, the way in which data is collected makes firm conclusions difficult, says Dr Male.

She argues that approaches better equipped to compare rates of menstrual changes in vaccinated versus unvaccinated populations are needed, and points out that the US National Institutes of Health (NIH) has made US$1.67 million (RM6.99 million) available to encourage this important research.

Reports of menstrual changes after Covid-19 vaccination have been made for both mRNA (messenger ribonucleic acid) and adenovirus-vectored vaccines, she adds.

This suggests that if there is a connection, it is likely to be a result of the immune response to vaccination, rather than to a specific vaccine component.

Indeed, the menstrual cycle may be affected by the body’s immune response to the virus itself, with one study showing menstrual disruption in around a quarter of women infected with SARS-CoV-2.

If a link between vaccination and menstrual changes is confirmed, this will allow individuals seeking vaccination to plan in advance for potentially altered cycles, she explains.

In the meantime, Dr Male suggests British clinicians encourage their patients to report any changes to periods or unexpected vaginal bleeding after vaccination to the MHRA’s scheme.

And anyone reporting a change in periods persisting over a number of menstrual cycles, or new vaginal bleeding after menopause, should be managed according to the usual clinical guidelines for these conditions.

“One important lesson is that the effects of medical interventions on menstruation should not be an afterthought in future research,” she concludes.

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