Gold prices slipped as safe-haven demand eased after the White House said it had received an indication from China that it wanted a deal.
But the White House had nothing else to say and U.S. President Donald Trump said he would be happy to keep tariffs on Chinese imports in place.
The United States will raise tariffs to 25% from 10% on $200 billion worth of Chinese imports on Friday, according to its official journal. China said it would retaliate and the U.S. benchmark index closed the session lower.
"It's consistent with people being unsure about what's actually going to come out of Washington this week," said Keith Lerner, chief market strategist at SunTrust Advisory Services in Atlanta.
Reuters earlier quoted U.S. government and private-sector sources as saying China had backtracked on almost all aspects of a draft trade agreement.
Trade delegations from Washington and Beijing are scheduled to begin their latest round of talks on Thursday.
Stocks on Wall Street initially rebounded, as did major indices in Europe, on the White House announcement. But MSCI's gauge of equity performance in 47 countries closed down 0.22%.
Earlier in Asia, shares outside Japan closed 0.94% lower and Japan's Nikkei index lost 1.46%.
Two weeks ago, the market had viewed resolution of the trade talks as a foregone conclusion, and with it back on the table, volatility has picked up, said Yousef Abbasi, global market strategist at INTL FCStone Financial Inc in New York.
"People put on risk since late December and now they're having to grapple with uncertainty on a topic they were almost certain about two weeks ago," Abbasi said. "It puts you in a precarious position."
The Dow Jones Industrial Average rose 2.24 points, or 0.01%, to 25,967.33. The S&P 500 lost 4.63 points, or 0.16%, to 2,879.42 and the Nasdaq Composite dropped 20.44 points, or 0.26%, to 7,943.32.
Bond prices fell, with the benchmark 10-year U.S. Treasury note slipping 12/32 in price to push up its yield to 2.4907%.
Portuguese, Irish and Spanish yields hit historic lows and Portugal saw firm demand at an auction, but Italian yields rose on concerns over tension within Rome's ruling coalition.
Portuguese 10-year bond yields fell to a record low of 1.07 percent and Spain's 10-year bond yield fell to a more than two-year low of 0.94 percent. Irish long-dated bond yields dropped below 0.5 percent for the first time since December 2017.
The dollar index was flat, with the euro down 0.01% to $1.1189. The Japanese yen strengthened 0.11% versus the greenback at 110.14 per dollar.
West Texas Intermediate oil futures rose more than 1%, boosted by a surprise drawdown in U.S. crude stockpiles.
U.S. crude inventories fell by 4 million barrels in the week to May 3, the Energy Information Administration said. Analysts had expected an increase of 1.2 million barrels.
Brent crude futures settled up 49 cents at $70.37 a barrel. U.S. WTI crude futures rose 72 cents to settle at $62.12 a barrel.
U.S. gold futures settled down 0.3% at $1,281.40. Earlier they had touched $1,292.80. - Reuters
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