A U.S. Airman attaches a GBU-31 munitions system to an F-15E Strike Eagle in the U.S. Central Command area of responsibility, December 19, 2025, in support of Operation Hawkeye Strike as the U.S. military launched large-scale strikes against dozens of Islamic State targets in Syria in retaliation for an attack on U.S. personnel, U.S. officials said. U.S. Air Force Photo/Handout via REUTERS
Dec 19 (Reuters) - The U.S. military launched large-scale strikes against dozens of Islamic State targets in Syria on Friday in retaliation for an attack on American personnel, U.S. officials said.
A U.S.-led coalition has been carrying out airstrikes and ground operations in Syria targeting Islamic State suspects in recent months, often with the involvement of Syria's security forces.
President Donald Trump had vowed to retaliate after a suspected ISIS attack killed U.S. personnel last weekend in Syria.
Defense Secretary Pete Hegseth said the strikes targeted "ISIS fighters, infrastructure, and weapons sites" and that the operation was "OPERATION HAWKEYE STRIKE."
"This is not the beginning of a war — it is a declaration of vengeance," Hegseth said. "Today, we hunted and we killed our enemies. Lots of them. And we will continue," he added.
Trump said on social media that the Syrian government fully supported the strikes and that the U.S. was inflicting "very serious retaliation."
U.S. Central Command said the strikes hit more than 70 targets across central Syria, adding that Jordanian fighter jets supported the operation.
One U.S. official said the strikes were carried out by U.S. F-15 and A-10 jets, along with Apache helicopters and HIMARS rocket systems.
Syria reiterated its steadfast commitment to fighting Islamic State and ensuring that it has "no safe havens on Syrian territory," according to a statement by the foreign ministry.
Two U.S. Army soldiers and a civilian interpreter were killed on Saturday in the central Syrian town of Palmyra by an attacker who targeted a convoy of American and Syrian forces before being shot dead, according to the U.S. military. Three other U.S. soldiers were also wounded in the attack.
About 1,000 U.S. troops remain in Syria.
The Syrian Interior Ministry has described the attacker as a member of the Syrian security forces suspected of sympathizing with Islamic State.
Syria's government is led by former rebels who toppled leader Bashar al-Assad last year after a 13-year civil war, and includes members of Syria's former Al Qaeda branch who broke with the group and clashed with Islamic State.
Syria has been cooperating with a U.S.-led coalition against Islamic State, reaching an agreement last month when President Ahmed al-Sharaa visited the White House.
(Reporting by Idrees Ali and Phil Stewart; Additional reporting by Costas Pitas, Menna Alaa El-Din and Yomna Ehab; Editing by Caitlin Webber, Diane Craft and Edmund Klamann)
