Chinese researchers discover new anti-aging gene therapy


BEIJING, Jan. 8 (Xinhua) -- For the first time, a genome-wide CRISPR-based screening technology has identified a new driver of cellular senescence. It can form part of new strategies to delay aging and prevent aging-associated diseases, Chinese researchers said.

By screening and identifying more than 100 genes responsible for the aging of human cells, the research team demonstrated that knocking out, or disabling, some genes by CRISPR can discourage the aging of human mesenchymal precursor cells (hMPCs). Among the genes that lead to senility, and KAT7 (a histone acetyltransferase), is one of the catalysts for aging.

Knocking out KAT7 has been proven effective in alleviating cellular senescence in the team's experiments, said Zhang Weiqi, a researcher at the Beijing Institute of Genomics under the Chinese Academy of Sciences. The scientists managed to reduce the proportion of the senescent cells in the livers of aged mice and prolonged the lifespan of physiologically aged mice and those with progeria.

The novel gene therapy, based on disabling a single gene or using KAT7 inhibitors, could extend mammal life. It could also slow down the aging of human liver cells. It suggests a massive potential for its application in translational medicine against human aging.

The study was published on Thursday in Science Translational Medicine online.

Article type: metered
User Type: anonymous web
User Status:
Campaign ID: 18
Cxense type: free
User access status: 3
   

Did you find this article insightful?

Yes
No

100% readers found this article insightful

Next In World

France says regrets Iran decision on nuclear talks, working to finding solution
Zamfara state govt in talks with kidnappers of 317 Nigerian schoolgirls - officials
Armenians barge into government building to demand PM's exit - RIA
This year's Nobel Peace Prize draws hundreds of nominees
UK demands Myanmar stop killing protesters
U.N. rights experts blame Russia for attempt to kill Navalny
French court finds former President Sarkozy guilty of corruption
First UAE ambassador arrives in Israel, eyes Tel Aviv embassy
Tokyo asks China to stop anal swab tests for Covid-19 on Japanese citizens
Harris favourite to win 2024 U.S. presidential election - UK bookmaker

Stories You'll Enjoy


Vouchers