Explainer - The new coronavirus variant in South Africa: Are concerns justified?

FILE PHOTO: Passengers wearing protective masks walk to the check-in counters at the O.R. Tambo International Airport in Johannesburg, South Africa, December 22, 2020. REUTERS/Siphiwe Sibeko/File Photo

JOHANNESBURG (Reuters) - South Africa has identified a new variant of the novel coronavirus, which authorities believe is driving a surge in COVID-19 infections that could overwhelm its healthcare system.

Several countries, including Britain which has found the mutant variant in cases linked to South Africa, have banned flights from South Africa, disrupting holiday travel and frustrating tour operators.


The new variant, referred to as 501.V2, was discovered by a network of scientists around South Africa who have been tracking the genetics of the SARS-COV-2 virus.

The variant appears to be focused in the south and southeast regions of the country and has been dominating findings from samples collected since October, they say.

First identified in Nelson Mandela Bay, along South Africa's east coast, it spread rapidly to other districts in the Eastern Cape, and to the Western Cape and KwaZulu Natal (KZN) provinces.

Scientists say the variant is different from others circulating in South Africa because it has multiple mutations in the important "spike" protein that the virus uses to infect human cells.

It has also been associated with a higher viral load, meaning a higher concentration of virus particles in patients' bodies, possibly contributing to higher levels of transmission.

Between 80% and 90% of new cases in the country are carrying the mutant variant, according to health authorities.


All viruses, including the one that causes COVID-19, change over time, and there have been hundreds of variations of this virus identified worldwide.

South African scientists say there is no clear evidence at this stage that this variant is associated with more severe disease or worse outcomes. However, it does appear to spread faster than previous iterations.

"What has happened with the sheer number of infections growing very fast is that's overwhelmed really fast the health care system," said Professor Tulio de Oliveira, director of the KZN Research Innovation and Sequencing Platform (KRISP), who helped conduct genome sequencing on South Africa’s mutant variant. "And when that happens, we have a big spike of increased mortality."

The positivity rate - or the percentage of all coronavirus tests performed that are actually positive - stood at 26% as of Dec. 23, around double the average rate of infection before December, when the virus showed signs of waning.

In the first wave of infections, which peaked during the winter months between June and July, the positivity rate reached as high as 27%.

"The rate of spread is much faster than the first wave and we will surpass the peak of the first wave in the coming days," health minister Zweli Mkhize said on Wednesday.


The variants reported by South Africa and the UK share a common change in the spike protein that may make them more infectious. But they are different variants, and sequence analysis revealed that they originated separately, the World Health Organization said.

Dr Andrew Preston, reader in microbial pathogenesis at the University of Bath, said, "The 'South African' variant is distinct from the UK variant, but both contain an unusually high number of mutations compared to other SARS-CoV-2 lineages."


South African authorities say it is too early to say whether the vaccines currently being deployed in Britain and the United States, or other COVID-19 shots in development, will protect against the new variant.

Vaccine developers including AstraZeneca, BioNTech and Moderna Inc said this week that they expect their shots to still work against the UK variant.

(Reporting by Mfuneko Toyana; Editing by MacDonald Dzirutwe, Alexandra Zavis & Shri Navaratnam)

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