Calorie restriction could slow ageing and preserve memory

While scientists caution that calorie restriction is not the path to the fountain of youth, the study does give researchers more insight to gene expressions. - AFP

Classic diets that make you feel really hungry may slow down ageing genes.

Going on a diet – the old fashioned kind that heeds no promise to curb hunger – can halt the normal rise and fall of over 900 different genes related to ageing and memory formation in the brain, according to a team of neuroscientists at New York University's Langone Medical Center.

Their findings, based on experiments with mice, could explain how fewer calories from carbohydrates inhibit some aspects of ageing and chronic diseases in humans.

"Our study shows how calorie restriction practically arrests gene expression levels involved in the ageing phenotype," says senior study investigator and NYU Langone neuroscientist, Stephen D. Ginsberg, PhD.

While the study adds evidence to the role of diet in ageing and in curbing age-related disease, it doesn't mean that calorie restriction is the path that leads to the fountain of youth, remarks Ginsberg.

Rodents, he says, have been known to thrive on a calorie-restricted diet and how much of the mouse model can be applied to humans isn't certain, particularly in the domain of memory.

Ginsberg's model, however, encompassed the dietary impact on over 10,000 genes, whereas previous research has examined one or two genes at a time.

In the study, dementia-prone female mice were fed pellets that represented a 30% reduction in calories by comparison with their regular diet.

Tissue analysis of the hippocampus was performed as the mice reached middle to late adulthood, revealing the positive effects on memory. – AFP Relaxnews