Device that cools the scalp may help cancer patients save their hair


By AGENCY
  • Wellness
  • Wednesday, 12 Aug 2015

Wigs may seem like fancy accessories but for those undergoing chemotherapy, it may be a necessity.

As a baby, Kim Nyalka’s now seven-year-old daughter would twist her fingers through her mother’s hair as she fell asleep, and playing with her mother’s hair is still a treasured habit.

So, when Nyalka found out that she’d have to have chemotherapy for breast cancer, she started first looking into wigs, and then into scalp cooling – a treatment that uses cold caps on the head to prevent hair loss during chemo – to make the process less traumatic for her family.

A year into her chemotherapy treatments, Nyalka, 47, of Whitehall, Pennsylvania, United States, has indeed kept her hair. It has been a cumbersome process, with each treatment requiring 80 pounds of dry ice, hundreds of dollars, hours of brutal cold and plenty of assistance from her husband, but for her, it’s been worth it.

“It’s really made this past year of treatment much less of an issue – for me and for my family,” she said. “Just for keeping normalcy in our family, not having her worry, and not having her be afraid.”

Scalp cooling, which has not been widespread in the US, may be on the verge of mainstream acceptance. One brand of the caps, DigniCap, is nearing approval by the US Food and Drug Administration and will be available for use on a limited basis at Magee-Womens Hospital of University of Pittsburgh Medical Center (UPMC) once that approval comes through.

Nyalka has a brand called Penguin Cold Caps, invented in England about two decades ago and used in the US for about 15 years. The devices are not FDA-approved, so patients must rent them from the company and operate them themselves.

Chemotherapy works by attacking dividing cells, such as cancer cells, but also those in hair follicles. Scalp cooling constricts the blood vessels that lead to the hair follicles, reducing the amount of the chemo drugs that reach the follicles.

The manufacturer of Penguin Cold Caps says that the technology is effective in about 86% of patients, though that figure varies depending on the specific chemo drug.

A five-year US clinical trial of the DigniCap, released recently at the American Society of Clinical Oncology (ASCO), found that the caps prevented hair loss in 70% of patients, versus the control group where 100% experienced significant hair loss.

In the US, only those enrolled in clinical trials have had access to DigniCaps.

Thousands of people in the US have used Penguin Cold Caps over the years, and about 350 are using them at any given time, though “in Pittsburgh the numbers appear to be lower than elsewhere”, said Frank Fronda, the company’s inventor and director.

Nyalka has received chemo treatments at Allegheny General Hospital every three weeks for about a year. For each treatment, she and her husband pick up 80 pounds of dry ice from a facility in the area and load it into special coolers they purchased. The caps are rented from the company for about US$600 (RM2,310) per month, and must be cooled to a precise temperature – minus 5.55°C – that is colder than standard freezers.

Her scalp must be pre-cooled by the caps before the chemotherapy begins, and the caps are left on during the therapy and for about three to four hours afterward.

The caps also must be changed for a freshly cooled one about every half hour to maintain the correct temperature.

“When I first put them on, particularly during the first cooldown, it’s so cold it hurts,” said Nyalka, who wears heated blankets during treatments. “You sort of get used to it, and then it doesn’t bother me as much.”

In many other cities in the US, the process is somewhat simpler.

A Minneapolis-based foundation called The Rapunzel Project, which works to make scalp cooling easier for cancer patients, has donated medical freezers to dozens of cancer centres and hospitals around the US when the facility or a patient has requested them.

When Nyalka brought up the caps with her doctor, he didn’t discourage her from using them, but said he wasn’t convinced of their effectiveness.

Other doctors are more sceptical.

“I don’t personally recommend or use them,” said Helen Analo, an oncologist with Allegheny Health Network. “It’s uncomfortable, it’s not that effective, and most women regain their hair anyway after chemotherapy.”

Dr Analo said that she has concerns about the possibility that the caps will create a “cancer sanctuary” in the scalp because the chemotherapy drugs are reduced there, citing two case reports of patients who used scalp cooling and contracted cancer in the scalp years after treatment.

For Adam Brufsky, co-director of the comprehensive cancer centre at Magee-Womens Hospital and the University of Pittsburgh Cancer Center, the recent DigniCap study presented at ASCO satisfied his concerns about the possibility of scalp cancer.

Infographic on a device that reduces hair loss during chemotherapy treatments. Contributed by the Pittsburgh Post-Gazette
Infographic on a device that reduces hair loss during chemotherapy treatments. Contributed by the Pittsburgh Post-Gazette

The study found no evidence of an increase in scalp metastases in patients who have used scalp cooling.

He knows of UPMC patients who have “very very uncommonly” used cold caps over the years. “The older technology does work, but it’s cumbersome and hard to use,” he said.

The newer DigniCaps stay on the patient’s head for the duration of the chemotherapy and do not need to be changed, keeping their temperature constant by circulating a cold gel through the cap.

Even after the likely FDA approval, they will be available on an extremely limited basis until the company perfects its technology and scales up production.

Magee is likely to get only one unit at first, said Dr Brufsky, which can be used by just two patients at a time.

At the same time, the impact on patients can be profound. “We’re really making chemotherapy a lot easier on people,” he said. “One of the biggest side effects is loss of hair. If this can address that, it’s wonderful.”

Newer companies, such as Dallas-based Chemo Cold Caps and the British Paxman Scalp Cooling, are also available for purchase or in clinical trials.

The effect of hair loss on cancer patients is about more than just vanity, said Nancy Marshall, co-founder of the Rapunzel Project, and a breast cancer survivor herself.

“If you have heart disease and you walk down the street, no one knows. When you have diabetes, no one knows – your medical situation is your business. When you have cancer, it’s everyone’s business.”

She cites the benefits on a patient’s identity, privacy and empowerment that can come from preserving the hair during chemotherapy.

Nyalka is happy to have her daughter laugh about the “funny cap” she wears home from chemo treatments – while still running her fingers through Nyalka’s hair. She is thankful that she was able to afford the caps and follow the protocol, and would like others to be able to share in that experience. – Pittsburgh Post-Gazette/Tribune News Service

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