The overhaul, first reported by the Financial Times, will also include shrinking or shutting equity and rates trading businesses outside of Europe.
The bad bank would house or sell assets valued at up to 50 billion euros ($56.06 billion)- after adjusting for risk - and comprising mainly long-dated derivatives.
The measures are part of a significant restructuring of the investment bank, a major source of revenue for Germany's largest lender, which has struggled to generate sustainable profits since the 2008 financial crisis.
It is trying to turn itself around, but has faced hurdles such as allegations of money laundering and failed stress tests.
Its attempt to create a German champion through a merger with Commerzbank failed in April.
In May, Chief Executive Officer Christian Sewing promised shareholders "tough cutbacks" at its underperforming investment bank.
Shares in Deutsche, which have recently traded at record lows, were up 2% in Frankfurt to top the list of German blue chip shares.
Deutsche said in an emailed statement in response to the FT report that it was "working on measures to accelerate its transformation so as to improve its sustainable profitability. We will update all stakeholders if and when required".
The effort by Sewing marks a further shift by the German lender away from investment banking to focus on more stable forms of revenue, such as transaction banking.
The bank is planning cuts at its U.S. equities business, including prime brokerage and equity derivatives, to win over shareholders unhappy about its performance, four sources familiar with the matter told Reuters in May.
Deutsche created a similar division for non-core investments in 2012 with 128 billion euros in risk-weighted assets. Deutsche wound up the unit nearly four years later, in 2016.
Sewing is expected to announce changes in July. The bank reports second-quarter earnings on July 24. - Bloomberg
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