In Sunday’s race at the Valencia Ricardo Tormo Circuit, Quartararo lost the chance to fight for points after having to avoid a crash during the race and eventually finished 14th.
Last year the Frenchman had a good outing at the same track – pole position and a second place finish – and will be looking to this Sunday’s second race at the same venue to revive his championship hopes.
The Petronas star now trails 37 points behind Spaniard world championship leader Joan Mir.
With just two rounds and 50-points remaining, the world championship is no longer in Quartararo’s own hands.
He also faces a tough fight with Spanish rider Alex Rins just to keep hold of second place.
Suzuki rider Mir is comfortably on top with 162 points while Quartararo tied with the second Suzuki flagbearer Rins in second place on 125 points.
“The championship is not over but we are focusing on other things right now, like trying to secure second place. Really disappointed but it’s like this and I can’t do anything,” said Quartararo.
“We will be working to try some things for this weekend, so I think we can improve the pace.
“We are still in the fight (for the title) but now I want to focus on having fun in these last two rounds, then we will see what we can fight for. I am hoping that it stays dry this weekend or at least that the weather is more consistent.
“Of course I won’t give up until we reach the chequered flag at Portimao.”
The final race will be at Portimao in Portugal on Nov 22.