The two back-to-back races will be the first race to allow fans inside the track, which previously hosted 60,000 spectators.
At the behest of local authorities, a crowd of 10,000 will get to see the action every day provided that they adhere to the strict standard operating procedure.
The Petronas Yamaha Sepang Racing Team rider celebrated a debut MotoGP podium when he finished second at the Czech Republic Grand Prix in Brno last month and currently sits 11th in the world championship. However, he failed to finish the last two rounds in Austria.
But he is feeling optimistic ahead of the race.
“Misano is my home track and so, of course, I like it a lot. The layout is quite tricky because originally, you used to ride it in the opposite direction.
“This has created some unique characteristics. It’s also quite twisty and narrow but these things also make it a great circuit to ride.
“It’s a great feeling to have two races in my backyard. In addition, we will have for the first time this season some fans in the stands.
“That’s great news because it means this is a first step towards normality. It will be great, especially for the Italian riders to have the crowd cheering us on.
“I hope we can give them a good show,” added Morbidelli, who finished fifth at the track last year.