I have allergies – Can I take the Covid-19 vaccine?


As Malaysia implements the national Covid-19 vaccination programme, those of us who are healthcare professionals have numerous friends and acquaintances asking us about the safety of the vaccines. In particular is the issue of the risk of being vaccinated if we have a history of allergies.

It is recognised that some individuals experience a serious but rare side effect: a severe allergic reaction called anaphylaxis. Anaphylaxis can occur after taking a drug, getting stung by a bee, eating something, etc, and not just from vaccines – and we often never know who is going to react in this way.

This severe reaction may cause swelling of the face or body, breathing difficulties and a drop in blood pressure. It is recognised that a few people have developed such reactions after taking the Covid-19 vaccine. So we need to be informed about this and be able to discuss risks with our doctor if we suffer from allergies.

As always it is important to look at the data and the evidence instead of relying on opinions or rumour. I have attempted to summarise our understanding about the risk of anaphylaxis from current available data.

How common is anaphylaxis after getting a Covid-19 vaccine?

I have summarised the data from three different countries: the US Centers for Disease Control and Prevention’s (CDC) Vaccine Adverse Event Reporting System, Britain’s Department of Health Yellow Card reporting system and Norway’s ADR Registry of the Norwegian Medicines Agency.

After more than 27 million doses there were 276 confirmed anaphylaxis events which gives a rate of 10.2 cases per million doses or 1 per 100,000 persons vaccinated. There are different rates of anaphylaxis in different countries (because if different genetic backgrounds) and possibly different rates with different vaccines (need more data here).

This however means that anaphylaxis after getting a Covid-19 vaccine is a very rare event. Note that all the persons who experienced anaphylaxis were treated and discharged fully recovered.

Do we need more data?

Ideally, we would like to see data that shows the risk of anaphylaxis in people who had prior anaphylaxis, and the risk of anaphylaxis in people with major or serious allergies (by type of vaccine).

In other words, we’re asking of all people with serious allergies who were vaccinated, how many actually developed anaphylaxis? The percentage (or rate) must be very, very small as many persons have allergies.

Some idea of this comes from a CDC report that describes 21 persons who developed anaphylaxis after getting a Covid-19 vaccine. Of those 21 people, 17 (or 81%) had a documented past history of allergies or allergic reactions to drugs, medical products, foods and insect stings. And seven out of 21 (or 33%) had experienced an episode of anaphylaxis in the past (one after a rabies vaccine, one after an influenza A H1N1 vaccine).

Hence the risk of anaphylaxis is higher in those who have a past history of allergies and is lower for those with no history of allergies. But remember that a very large number of persons with allergies have had the vaccine safely with no reactions.

What constitutes a severe allergy?

Many people may have some allergy, often a mild one – it is estimated that 20%-30% of the population has some allergies. Common mild allergic conditions would include eczema, allergic rhinitis, food allergies, urticaria, contact dermatitis, insect allergies, mild asthma, etc.

Examples of moderate allergic conditions would be drug allergies and severe asthma, especially when not controlled. Severe allergies would be a previous anaphylaxis, or prior angio-oedema (cutaneous oedema without blood pressure or respiration changes) or previous hypersensitivity reactions to vaccines or vaccine components (especially polyethylene glycol).

What do international organisations recommend?

International organisations or regulatory bodies have made statements about Covid-19 vaccine use and allergies. Note that most support vaccination in those with prior allergies and some even in those who have had prior anaphylaxis (with close observation).

But all do not support vaccination in anyone who has had a prior reaction to Covid-19 vaccines or a reaction to other vaccines or drugs that contained polyethylene glycol or polysorbate 80.

Some are more cautious and conservative and hope for more data before removing some contraindications to vaccination.

What does Malaysia’s Health Ministry advise?

The national Covid-19 immunisation programme booklet states that “The Covid-19 vaccine is safe for the majority of people. However, some groups will need further consideration prior to receiving the vaccine”. This includes “individuals with severe allergies”.

The ministry’s National Pharmaceutical Regulatory Agency has an FAQ section about the Pfizer-BioNTech (Comirnaty) vaccine. On allergies, it states “Comirnaty should not be given to individuals who are known to have allergic reactions to any of the ingredients in the vaccine.... The second dose of the vaccine should not be given to individuals who had a severe allergic reaction after the first dose of this vaccine.”

The agency also advises individuals with allergies to speak to their doctor before deciding on their suitability for vaccination but says that you may receive the vaccine even if you have an allergy.

It would be good if clearer guidelines were made available to all doctors and healthcare staff so they can advise those coming for vaccination. The Health Ministry will be monitoring all side effects after vaccination and encourages us to report them.

What do I do if I have severe allergies?

Having read all that, you may ask: What do I do if I am in the category of persons with prior anaphylaxis or angio-oedema or a large number of bad drug allergies? Well, I am in the same situation as you are. I have numerous drug allergies, some very severe (Steven Johnson reaction, a rare, serious disorder of the skin and mucous membranes); I have had an angio-oedema episode, one allergic airway obstruction and also have underlying asthma and eczema.

We want to support the national Covid-19 vaccination programme, we want to help protect others by getting vaccinated and we certainly do not want our lives restricted if we don’t get vaccinated (if the government or businesses impose conditions on those not vaccinated).

I believe there are three possible options for those of us with severe allergies:

> Firstly we may choose not to get vaccinated as we feel the risk is too high. But we will have to accept a much stricter SOP for our lives and be prepared to have our life restricted for some time.

> The second option is that we choose to vaccinate and, due to the high risk, ask that it be done with enhanced health professional support, ie vaccinate in a hospital and have good physician backup with adrenaline at hand.

> The third option is to delay vaccination and watch the data as more is made available. The risk of anaphylaxis is small and likely to be even smaller as we get more vaccination data.

We will also have a clearer idea of which vaccine has the lowest rate of severe allergic reaction. Once this data is available we hope to be able to choose the vaccine that causes the least allergic reactions and vaccinate in a hospital with good physician backup.

Note that this advice only applies to those with severe allergies. Those with milder allergies should consider getting vaccinated but should inform their doctor about their allergies. Hundreds of thousands of persons with allergies have already had the vaccine safely.

It would be good if when registering for vaccination on the MySejahtera app there is a clear box to check for past allergies. Currently we have only an “Others” box to tick.

In this discussion we must remember that the chance of dying from Covid-19, especially if you past 60 years, like me, is much, much higher than any vaccine risk. Not to mention the 10%-20% who may suffer from “long Covid-19”, which is quite debilitating. As always, we must appreciate that our vaccination will help protect those who cannot get vaccinated, especially children and those currently contraindicated due to poor health.

What we need is full data transparency, especially about adverse events. Rapid, open granular data-sharing with the public kills rumours and aids the vaccination programme.


Senior consultant paediatrician

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Covid-19 , vaccines , vaccination , allergies


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