CHICAGO, Nov. 24 (Xinhua) -- One key gut hormone, released a few hours after eating, turns off fat production by regulating gene expression in the liver. This regulation is abnormal in obesity, according to a study posted on the website of the University of Illinois (UI) on Tuesday.
In the study, the researchers found that the gut hormone FGF15 in mice and its human counterpart FGF19 turn off fat-producing genes in the liver. The hormones are released a few hours after eating, when the body transitions from feeding to fasting. FGF15/19 activate regulatory molecules to enter the nucleus, the center of the cell where DNA is stored, and inhibit gene expression.
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