Cholesterol metabolite causes immune system to attack T cells: study


By Xu Jing
  • World
  • Tuesday, 15 Sep 2020

CHICAGO, Sept. 14 (Xinhua) -- A study in mice found that in breast cancer tumors, a molecule produced when the body breaks down cholesterol hijacks the myeloid immune cells that normally arm T cells to fight cancer. Instead, the hijacked myeloid cells disarm the T cells and even tell them to self-destruct.

By inhibiting the enzymes that make that molecule, researchers at the University of Illinois (UI) slowed the cancer's progression and boosted the efficacy of immune therapy in the mice, according to the study posted on UI's website on Monday.

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