The three men were travelling in the vegetable-laden truck when the driver lost control of the vehicle at about 1pm.
The lorry skidded, overturned and burst into flames.
Sabah Fire and Rescue Department operations chief Khatizah Rahaban said the three managed to crawl out of the truck and ran to safety.
She said the lorry was totally burnt following the mishap.
“Two of them - 37-year-old Samat Kerama and 15-year-old Mike Kenzie Felix - sustained minor injuries while the other man was not hurt,” she said in a statement.
Those injured were taken to hospital for treatment.