New booster shot option

BEIJING: An inhalable Covid-19 vaccine developed by CanSino Biologics has been shown to be safe and effective at triggering the production of neutralising antibodies, making it a possible booster shot option that is accessible and painless to administer, a study published in the journal The Lancet Respiratory Medicine said.The vaccine is an aerosol version of Convidecia, a single-dose adenovirus-based viral vector vaccine that was granted emergency use listing by the World Health Organisation (WHO) last week.

It was the 11th Covid-19 vaccine validated by the WHO and was found to have 64% efficacy against symptomatic disease and 92% efficacy against severe Covid-19.

The study, published last Friday, examined the safety and immune response of the inhalable vaccine when used as a booster shot for people who had received two doses of an inactivated vaccine.

With a sample size of 420 participants, the study found that the new vaccine is generally safe and can produce significantly higher levels of neutralising antibodies in volunteers compared with those who received an inactivated vaccine as a booster shot.

The most common adverse reactions for the testing group included fatigue, headaches and fever, the study said. No severe adverse events were reported.

As for immunogenicity, participants who received the inhalable vaccine as a booster had generated 18.4 to 26.4 times higher levelx of neutralising antibodies.

Another key finding for the inhalable vaccine is that it only requires about one-fifth to two-fifths of the dosage in the original Convidecia vaccine to trigger an immune response, the study said.

In addition, it can bolster the immune response in cells that form the mucous membrane in the upper airways, which is the first line of defence against respiratory viruses. Respiratory mucosal protection is a property that vaccines delivered through intramuscular injections lack. — China Daily/ANN

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