Researchers in Singapore have come up with a way to fight superbug infections by combining antibiotics into more effective cocktails.
They have developed three antibiotic combinations to not only kill the drug-resistant bacteria but also slow down its mutation to become resistant.
The different antibiotic types in each combination complement one another by fighting bacteria in different ways, for instance by destroying bacterial cell walls.
Laboratory tests showed the three-drug combos killed even multi-drug resistant bacteria strains like Pseudomonas aeruginosa and Klebsiella pneumoniae, and were more potent than any single drug alone.
This means doctors could potentially reduce dosages and the number of days patients need to take the antibiotics for infections, leading to fewer side effects and lower cost of treatment.
The scientists from the Agency for Science, Technology and Research’s Institute of Chemical and Engineering Sciences (Ices) and a local hospital intend to submit their findings to a scientific journal by next month.
They have patented the three drug cocktails, and are working on powder versions that can be inhaled, similar to an inhaler for asthmatic patients.
The scientists said they hope to test the formulas on small animals within a year, and move on to human trials if the results are promising. — The Straits Times / Asia News Network