Columnists

Global Trends

Published: Monday October 13, 2014 MYT 12:00:00 AM
Updated: Monday October 13, 2014 MYT 7:20:14 AM

New hepatitis cure far too costly

A new cure for hepatitis C has given new hope, but its price is far too high, while a scheme to supply poor countries excludes Malaysia and other middle-income countries.

A CONTROVERSY is brewing over a new cure for hepatitis C because it is extremely expensive and patients in middle-income countries like Malaysia will find it way beyond their budget.

There are an estimated 400,000 Malaysians with hepatitis C, but this is probably a significant under-estimate since many people are not aware that they have the virus.

Worldwide, 170 million people live with the hepatitis C virus (HCV), and every year three to four million more are infected, and there are around 350,000 deaths.

Hepatitis C is thus a major public health problem and called a “silent killer” because it can lead to serious liver ailments including cancer for those who are infected.

The good news is that a new drug, sofosbuvir, was approved last year by the American health authorities.

The medicine has an effective rate of around 90%, making it superior to the older medicines which have a lower success rate and some serious side effects.

The bad news is that the producer, the US firm Gilead, put a very high price tag of US$84,000 (RM274,428) for a 12-week course.

Each pill thus costs US$1,000 (RM3,267).

The price could be set so high because the older and less effective alternatives cost about a third of that level, and the company also argued that a liver transplant (which the new medicine’s cure would make unnecessary) would cost much higher.

Revenue from the new medicine since late last year has already run into many billions of dollars.

At that kind of price, only the very rich can afford the new medicine.

Patients in the West have difficulty even if they are insured, as the insurance companies or the National Health Service might not be able to put this expensive drug on their approved list.

There is now a wave of anger among health and patients’ groups throughout the world.

Here is a life-saving medicine which is being priced out of reach, because the patents being filed by the company prevents competitors producing cheaper versions.

Opposition to a patent application was filed in India by a group, Initiative for Medicines, Access and Knowledge, on the ground that the drug made use of an existing compound.

In Indian law, patents need not be given for new uses of existing medicines or their compounds.

Facing mounting opposition, Gilead came up with a new initiative.

It made agreements with seven companies in India, allowing them to produce their own versions of sofosbuvir as well as another medicine, ledipasvir (which can be taken in combination), at prices these companies will set themselves.

A study at Liverpool University found that a full course of generic sofosbuvir could cost as low as US$101 (RM330) and ledipasvir, US$93 (RM303).

Another estimate is that the cost could be US$135-US$400 (RM441-RM1,306).

Thus the Indian companies’ prices are expected to be well below a thousand dollars.

An example from a decade ago is useful. When medicines for HIV-AIDS sold for US$15,000 (RM49,005) a patient a year, Indian companies produced generic versions for US$350 (RM1,143) a patient a year, and their prices fell further to about US$65 (RM212) today.

There is, however, a major flaw in this new plan. While the agreements allow the Indian companies to sell the medicine in India and in some other countries, they are not allowed to market it in 51 middle-income developing countries.

Malaysia is one of these countries, together with 50 others including Thailand, the Philippines, China, Brazil and Argentina.

Patients and governments in these countries will thus be blocked from obtaining the cheap medicine coming from India.

The originator company plans to sell its brand in these excluded countries and thus reap high profits.

The price they charge may be less than US$84,000 (RM274,428), but significantly higher than the Indian companies’ prices.

The medical group, Medicins Sans Frontiers, has criticised this discrimination.

It said: “Hepatitis C is especially prevalent in middle-income countries, with approximately 73% of the burden in these countries. But disappointingly many of these countries remain excluded from accessing Gilead’s lowest price and the generic versions licensed by these agreements.”

Patients in the excluded countries have expressed their anger. In Malaysia, the Positive Malaysian Treatment Access and Advocacy Group and the Third World Network said the new oral medicines bring new hope for hepatitis C patients but these hopes were dashed by the restrictive terms of the agreements, thus “condemning to death many of the 50 million HCV patients living in territories excluded from the scope from the voluntary licence such as Malaysia, Thailand, Philippines and China”.

Thirteen Thai NGOs issued a statement that they are appalled by the agreement that the originator signed with the Indian companies, which they said represented “corporate greed building yet another barrier to access to a new medicine needed by millions with hepatitis C infection in middle-income countries.

“In those middle-income countries not included in the deal, millions of people will be effectively handed a death sentence as the new life-saving medicine will be unaffordable.”

The Brazilian Network for Integration of Peoples said it “vehemently repudiates the agreements which treat medicines as commodities, preventing millions of people to have access to medicines”.

Patients in the affected countries, and their support groups, including the above, are calling on their governments to act to ensure that their citizens have access to the new medicines.

The countries are allowed by the WTO’s intellectual property agreement not to grant patents if the medicines are not new or genuine inventions.

If patents have been granted, the governments can issue compulsory licences that allow generic companies or government firms to produce and sell generic medicines at cheap prices.

Alternatively, the governments can ask the company to include their countries to be among those that the Indian companies can supply to, or else that the prices charged by the company are the same as the cheapest generics.

> Martin Khor is executive director of the South Centre, a research centre of 51 developing countries, based in Geneva. You can e-mail him at director@southcenter.org. The views expressed here are entirely his own.

Tags / Keywords: Martin Khor

More Articles

Filter by

New hepatitis cure far too costly

13 October 2014

A new cure for hepatitis C has given new hope, but its price is far too high, while a scheme to supply poor countries excludes Malaysia and other middle-income countries.

An era of global turbulence

29 September 2014

Leaders meeting at the United Nations are facing a world under attack, and responses are so far not matching the manifold crises.

Battling to curb ‘vulture funds’

15 September 2014

Many countries face a worsening debt situation compelling an urgency to

In defence of Merdeka

1 September 2014

Independence has been achieved, yet has to be constantly defended, continuously renewed and expanded as the process of de-colonisation is on-going and new threats arise.

Alarm bells over Ebola outbreak

18 August 2014

Ebola is a deadly disease, with no approved cure. This raises various issues, and urgent steps must be taken to contain and fight it.

The Gaza carnage must stop

4 August 2014

The death and destruction going on in Gaza show that ‘the world has lost its humanity’ and that Israel has utter contempt for the United Nations.

Raining death: An Israeli artillery unit hammering the Gaza Strip. - AFP

Hit by two calamities

21 July 2014

The world must face up to the two calamities of the past week — the crash of the MAS plane and the worsening plight of Palestinians.

Overloaded 'trade deals'

7 July 2014

ONCE upon a time, trade agreements were just about trade. The negotiator’s principle was: I’ll allow some of your products to enter my market if you allow some of mine to sell in yours.

Marking 50 years of G77

23 June 2014

Leaders of the developing world gather to make a declaration on how to improve the world order and their own national development.

Action to use medicines wisely

16 June 2014

A resolution by Health Ministers to formulate a global plan to deal with antibiotics resistance has given hope that action may finally be forthcoming.

advertisement

Recent Posts

advertisement